Large-scale variation in single nucleotide polymorphism density within the laboratory axolotl (Ambystoma mexicanum).

ABSTRACT:

Background

Recent efforts to assemble and analyze the Ambystoma mexicanum genome have dramatically improved the potential to develop molecular tools and pursue genome-wide analyses of genetic variation.

Results

To better resolve the distribution and origins of genetic variation with A mexicanum, we compared DNA sequence data for two laboratory A mexicanum and one A tigrinum to identify 702 million high confidence polymorphisms distributed across the 32 Gb genome. While the wild-caught A tigrinum was generally more polymorphic in a genome-wide sense, several multi-megabase regions were identified from A mexicanum genomes that were actually more polymorphic than A tigrinum. Analysis of polymorphism and repeat content reveals that these regions likely originated from the intent

SUBMITTER: Timoshevskaya N 

PROVIDER: S-EPMC8715502 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature