Tumor-derived biomimetic nanozyme with immune evasion ability for synergistically enhanced low dose radiotherapy.

ABSTRACT: High doses of radiation can cause serious side effects and efficient radiosensitizers are urgently needed. To overcome this problem, we developed a biomimetic nanozyme system (CF) by coating pyrite (FeS₂) into tumor-derived exosomes for enhanced low-dose radiotherapy (RT). CF system give FeS₂ with immune escape and homologous targeting abilities. After administration, CF with both glutathione oxidase (GSH-OXD) and peroxidase (POD) activities can significantly lower the content of GSH in tumor tissues and catalyze intracellular hydrogen peroxide (H₂O₂) to produce a large amount of ·OH for intracellular redox homeostasis disruption and mitochondria destruction, thus reducing RT resistance. Experiments in vivo and in vitro showed that combining CF w

SUBMITTER: Huang C 

PROVIDER: S-EPMC8715603 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature