Relationship of the lung microbiome with PD-L1 expression and immunotherapy response in lung cancer.

ABSTRACT:

Background

Lung cancer is the primary cause of cancer-related deaths worldwide. The human lung serves as a niche to a unique and dynamic bacterial community that is related to the development of multiple diseases. Here, we investigated the differences in the lung microbiomes of patients with lung cancer.

Methods

16S rRNA sequencing was performed to evaluate the respiratory tract microbiome present in the bronchoalveolar lavage fluid. Patients were stratified based on programmed death-ligand 1 (PD-L1) expression levels and immunotherapy responses.

Results

In total, 84 patients were prospectively analyzed, of which 59 showed low (< 10%), and 25 showed high (≥ 10%) PD-L1 expression levels. The alpha and beta diversities did not significantly differ between the two groups

SUBMITTER: Jang HJ 

PROVIDER: S-EPMC8715618 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature