Evaluation of Effects of Laboratory Disinfectants on Mouse Gut Microbiota.

ABSTRACT: Disturbances in the gut microbiota are known to be associated with numerous human diseases. Mice have proven to be an invaluable tool for investigating the role of the gut microbiota in disease processes. Nonexperimental factors related to maintaining mice in the laboratory environment are increasingly being shown to have inadvertent effects on the gut microbiota and may function as confounding variables. Microisolation technique is a term used to describe the common biosecurity practice of spraying gloved hands with disinfectant before handling research mice. This practice prevents contamination with pathogenic microorganisms. To investigate if exposure to disinfectants can affect the mouse gut microbiota, C57BL/6 mice were exposed daily for 27 consecutive days to commonly used laboratory

SUBMITTER: Sciurba JD 

PROVIDER: S-EPMC8715766 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature