Matrix Metalloproteinase-9 Gene Polymorphism and Its Methylation in Stroke Patients.

ABSTRACT:

Background

Genetic and environmental factors, along with hypertension, diabetes mellitus and smoking cause accelerated atherosclerosis and, eventually, stroke. Matrix metalloproteinase-9 (MMP-9) are inflammatory mediators of the endoproteinase family, and their polymorphism and methylation are associated with the development of atherosclerosis and stroke. This study explores this association in the Indian population.

Objective

To study the association of MMP gene polymorphism and methylation with the risk of stroke.

Methods

A case-control study was conducted on 100 admitted patients (both genders) diagnosed with ischaemic stroke. Another 100 healthy subjects, not suffering from any chronic illness or stroke, were taken as controls. All participants were genotyped for

SUBMITTER: Choudhari OK 

PROVIDER: S-EPMC8715877 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature