Prenatal Nicotine or Cannabis Exposure and Offspring Neurobehavioral Outcomes.

ABSTRACT:

Objective

To study the association between nicotine or cannabis metabolite presence in maternal urine and child neurodevelopmental outcomes.

Methods

We conducted a secondary analysis of two parallel multicenter randomized controlled trials of treatment for hypothyroxinemia or subclinical hypothyroidism among pregnant individuals enrolled at 8-20 weeks of gestation. All maternal-child dyads with a maternal urine sample at enrollment and child neurodevelopmental testing were included (N=1,197). Exposure was urine samples positive for nicotine (cotinine) or cannabis 11-nor-9-carboxy-delta-9-tetrahydrocannabinol [THC-COOH]) or both metabolites. Primary outcome was child IQ at 60 months. Secondary outcomes included cognitive, motor and language, attention, behavioral and social c

SUBMITTER: Smid MC 

PROVIDER: S-EPMC8715943 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature