GFR estimation is complicated by a high incidence of non-steady-state serum creatinine concentrations at the emergency department.

ABSTRACT:

Background

Acquiring a reliable estimate of glomerular filtration rate (eGFR) at the emergency department (ED) is important for clinical management and for dosing renally excreted drugs. However, renal function formulas such as CKD-EPI can give biased results when serum creatinine (SCr) is not in steady-state because the assumption that urinary creatinine excretion is constant is then invalid. We assessed the extent of this by analysing variability in SCr in patients who visited the ED of a tertiary care centre.

Methods

Data from ED visits at the University Medical Centre Utrecht, the Netherlands between 2012 and 2019 were extracted from the Utrecht Patient Oriented Database. Three measurement time points were defined for each visit: last SCr measurement before visit as base

SUBMITTER: Niemantsverdriet MSA 

PROVIDER: S-EPMC8716053 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature