Delilah, prospero, and D-Pax2 constitute a gene regulatory network essential for the development of functional proprioceptors.

ABSTRACT: Coordinated animal locomotion depends on the development of functional proprioceptors. While early cell-fate determination processes are well characterized, little is known about the terminal differentiation of cells within the proprioceptive lineage and the genetic networks that control them. In this work we describe a gene regulatory network consisting of three transcription factors-Prospero (Pros), D-Pax2, and Delilah (Dei)-that dictates two alternative differentiation programs within the proprioceptive lineage in Drosophila. We show that D-Pax2 and Pros control the differentiation of cap versus scolopale cells in the chordotonal organ lineage by, respectively, activating and repressing the transcription of dei. Normally, D-Pax2 activates the expression of dei in the cap cell but is una

SUBMITTER: Avetisyan A 

PROVIDER: S-EPMC8716109 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature