Molecular imaging of the serotonin transporter availability and occupancy by antidepressant treatment in late-life depression.

ABSTRACT: Patients with late-life depression (LLD) have a more variable response to pharmacotherapy relative to patients with mid-life depression. Degeneration of the serotonergic system and lower occupancy of the initial target for antidepressant medications, the serotonin transporter (5-HTT), may contribute to variability in treatment response. The focus of this study was to test the hypotheses that lower cortical and limbic serotonin transporter (5-HTT) availability in LLD patients relative to controls and less 5-HTT occupancy by antidepressant medications would be associated with less improvement in mood and cognition with treatment in LLD patients. Twenty LLD patients meeting DSM-IV criteria for a current major depressive episode and 20 non-depressed controls underwent clinical and neuropsychol

SUBMITTER: Smith GS 

PROVIDER: S-EPMC8716112 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature