Paradoxical sex-specific patterns of autoantibody response to SARS-CoV-2 infection.

ABSTRACT:

Background

Pronounced sex differences in the susceptibility and response to SARS-CoV-2 infection remain poorly understood. Emerging evidence has highlighted the potential importance of autoimmune activation in modulating the acute response and recovery trajectories following SARS-CoV-2 exposure. Given that immune-inflammatory activity can be sex-biased in the setting of severe COVID-19 illness, the aim of the study was to examine sex-specific autoimmune reactivity to SARS-CoV-2 in the absence of extreme clinical disease.

Methods

In this study, we assessed autoantibody (AAB) reactivity to 91 autoantigens previously linked to a range of classic autoimmune diseases in a cohort of 177 participants (65% women, 35% men, mean age of 35) with confirmed evidence of prior SARS-CoV-2 i

SUBMITTER: Liu Y 

PROVIDER: S-EPMC8716184 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature