Comparative description of the mRNA expression profile of Na⁺ /K⁺ -ATPase isoforms in adult mouse nervous system.

ABSTRACT: Mutations in genes encoding Na⁺ /K⁺ -ATPase α1, α2, and α3 subunits cause a wide range of disabling neurological disorders, and dysfunction of Na⁺ /K⁺ -ATPase may contribute to neuronal injury in stroke and dementia. To better understand the pathogenesis of these diseases, it is important to determine the expression patterns of the different Na⁺ /K⁺ -ATPase subunits within the brain and among specific cell types. Using two available scRNA-Seq databases from the adult mouse nervous system, we examined the mRNA expression patterns of the different isoforms of the Na⁺ /K⁺ -ATPase α, β and Fxyd subunits at the single-cell level among brain regions and various neuronal populations. We subsequently identified

SUBMITTER: Jiao S 

PROVIDER: S-EPMC8716420 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature