Characterization of the tumor immune microenvironment of sinonasal squamous-cell carcinoma.

ABSTRACT:

Background

Treatment and prognosis of sinonasal squamous-cell carcinoma (SNSCC) have not significantly improved despite improvements in radical therapy. Characterization of the tumor immune microenvironment (TiME) may identify patient subgroups associated with disease recurrence, and provide new biomarkers for improved patient stratification and treatment.

Methods

The TiME was quantitatively evaluated by multiplex immunohistochemistry (mIHC) in archived tissue sections from 38 patients with SNSCC, and were assessed for differences between recurrent (n = 20) and nonrecurrent (n = 18) groups. Hierarchical clustering analyses were performed to identify phenotypic TiME subgroups within the cohort and were used to compare survival outcomes.

Results

Our mIHC analysis reveal

SUBMITTER: Gu JT 

PROVIDER: S-EPMC8716469 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature