Nonclassical Monocytes Are Prone to Migrate Into Tumor in Diffuse Large B-Cell Lymphoma.

ABSTRACT: Absolute count of circulating monocytes has been proposed as an independent prognostic factor in diffuse large B-cell lymphoma (DLBCL). However, monocyte nomenclature includes various subsets with pro-, anti-inflammatory, or suppressive functions, and their clinical relevance in DLBCL has been poorly explored. Herein, we broadly assessed circulating monocyte heterogeneity in 91 DLBCL patients. Classical- (cMO, CD14^pos CD16^neg) and intermediate- (iMO, CD14^pos CD16^pos) monocytes accumulated in DLBCL peripheral blood and exhibited an inflammatory phenotype. On the opposite, nonclassical monocytes (ncMOSlan^pos, CD14^low CD16^pos Slan^neg and ncMOSlan^neg, CD14^low CD16^pos, Slan

SUBMITTER: Le Gallou S 

PROVIDER: S-EPMC8716558 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature