Deciphering the Role of Leptospira Surface Protein LigA in Modulating the Host Innate Immune Response.

ABSTRACT: Leptospira, a zoonotic pathogen, is known to infect various hosts and can establish persistent infection. This remarkable ability of bacteria is attributed to its potential to modulate (activate or evade) the host immune response by exploiting its surface proteins. We have identified and characterized the domain of the variable region of Leptospira immunoglobulin-like protein A (LAV) involved in immune modulation. The 11^th domain (A₁₁) of the variable region of LigA (LAV) induces a strong TLR4 dependent innate response leading to subsequent induction of humoral and cellular immune responses in mice. A₁₁ is also involved in acquiring complement regulator FH and binds to host protease Plasminogen (PLG), there by mediating functional activity to

SUBMITTER: Kumar A 

PROVIDER: S-EPMC8716722 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature