Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players.

ABSTRACT: Introduction: Biological aging is associated with changes in the metabolic pathways. Leukocyte telomere length (LTL) is a predictive marker of biological aging; however, the underlying metabolic pathways remain largely unknown. The aim of this study was to investigate the metabolic alterations and identify the metabolic predictors of LTL in elite male soccer players. Methods: Levels of 837 blood metabolites and LTL were measured in 126 young elite male soccer players who tested negative for doping abuse at anti-doping laboratory in Italy. Multivariate analysis using orthogonal partial least squares (OPLS), univariate linear models and enrichment analyses were conducted to identify metabolites and metabolic pathways associated with LTL. Generalized linear model followed by rec

SUBMITTER: Al-Muraikhy S 

PROVIDER: S-EPMC8716766 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature