The effect of local steroid application on bony fusion in a rat posterolateral spinal arthrodesis model.

ABSTRACT:

Introduction

Local steroid administration during anterior cervical spine surgery has been shown to improve postoperative dysphagia. However, concerns over potential complications remain. This study aims to evaluate the effect of local steroid administration on bone regeneration and spine fusion in a preclinical model, as well as the impact on osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBM-MSCs) in a 3D culture system.

Materials and methods

Forty-five rats underwent bilateral L4-L5 posterolateral lumbar fusion (PLF) utilizing local delivery of low-dose recombinant human bone morphogenetic protein-2 (rhBMP-2; 0.5 μg/implant). Rats were divided into three groups: no steroid (control), low dose (0.5 mg/kg), and high dose (2.5 mg/kg) of triamc

SUBMITTER: Kannan A 

PROVIDER: S-EPMC8717102 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature