Effect of Colchicine vs Usual Care Alone on Intubation and 28-Day Mortality in Patients Hospitalized With COVID-19: A Randomized Clinical Trial.

ABSTRACT:

Importance

Hospitalized patients with COVID-19 pneumonia have high rates of morbidity and mortality.

Objective

To assess the efficacy of colchicine in hospitalized patients with COVID-19 pneumonia.

Design, setting, and participants

The Estudios Clínicos Latino América (ECLA) Population Health Research Institute (PHRI) COLCOVID trial was a multicenter, open-label, randomized clinical trial performed from April 17, 2020, to March 28, 2021, in adults with confirmed or suspected SARS-CoV-2 infection followed for up to 28 days. Participants received colchicine vs usual care if they were hospitalized with COVID-19 symptoms and had severe acute respiratory syndrome or oxygen desaturation. The main exclusion criteria were clear indications or contraindications for colchicine,

SUBMITTER: Diaz R 

PROVIDER: S-EPMC8717104 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature