Kinetic and Static Analysis of Poly-(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted ¹⁸F-Fluorthanatrace PET Images of Ovarian Cancer.

ABSTRACT: The poly-(adenosine diphosphate-ribose) polymerase (PARP) family of proteins participates in numerous functions, most notably the DNA damage response. Cancer vulnerability to DNA damage has led to development of several PARP inhibitors (PARPi). This class of drugs has demonstrated therapeutic efficacy in ovarian, breast, and prostate cancers, but with variable response. Consequently, clinics need to select patients likely to benefit from these targeted therapies. In vivo imaging of ¹⁸F-fluorthanatrace uptake has been shown to correspond to PARP-1 expression in tissue. This study characterized the pharmacokinetics of ¹⁸F-fluorthanatrace and tested kinetic and static models to guide metric selection in future studies assessing ¹⁸F-fluorthanatrace as a biomark

SUBMITTER: Young AJ 

PROVIDER: S-EPMC8717190 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature