Heat stress-induced mucosal barrier dysfunction is potentially associated with gut microbiota dysbiosis in pigs.

ABSTRACT: Heat stress (HS) can be detrimental to the gut health of swine. Many negative outcomes induced by HS are increasingly recognized as including modulation of intestinal microbiota. In turn, the intestinal microbiota is a unique ecosystem playing a critical role in mediating the host stress response. Therefore, we aimed to characterize gut microbiota of pigs' exposure to short-term HS, to explore a possible link between the intestinal microbiota and HS-related changes, including serum cytokines, oxidation status, and intestinal epithelial barrier function. Our findings showed that HS led to intestinal morphological and integrity changes (villus height, serum diamine oxidase [DAO], serum D-lactate and the relative expressions of tight junction proteins), reduction of serum cytokines (interleuk

SUBMITTER: Xia B 

PROVIDER: S-EPMC8717382 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature