Preloading magnesium attenuates cisplatin-associated nephrotoxicity: pilot randomized controlled trial (PRAGMATIC study).

ABSTRACT:

Background

Cisplatin is one of the most potent chemotherapeutic drugs used in head and neck cancer treatment; however, nephrotoxicity is the major side-effect limiting usage. Magnesium supplementation has been reported to reduce risk in non-controlled studies. We investigated whether preloading with magnesium prevents nephrotoxicity with a low-dose weekly cisplatin regimen.

Methods

We carried out a prospective pilot, single-blinded, randomized controlled trial to compare cisplatin-associated acute kidney injury (cis-AKI) and acute kidney disease (cis-AKD) between two groups: intravenous 0.9% NaCl 500 ml + KCL 20 mEq over 4 h pre-cisplatin 40 mg/m² weekly for 7-8 weeks (control group) compared with additional 16 mEq magnesium added to the saline infusion (Mg group)

SUBMITTER: Suppadungsuk S 

PROVIDER: S-EPMC8717436 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature