CREB1^K292 and HINFP^K330 as Putative Common Therapeutic Targets in Alzheimer's and Parkinson's Disease.

ABSTRACT: Integration of omics data and deciphering the mechanism of a biological regulatory network could be a promising approach to reveal the molecular mechanism involved in the progression of complex diseases, including Alzheimer's and Parkinson's. Despite having an overlapping mechanism in the etiology of Alzheimer's disease (AD) and Parkinson's disease (PD), the exact mechanism and signaling molecules behind them are still unknown. Further, the acetylation mechanism and histone deacetylase (HDAC) enzymes provide a positive direction toward studying the shared phenomenon between AD and PD pathogenesis. For instance, increased expression of HDACs causes a decrease in protein acetylation status, resulting in decreased cognitive and memory function. Herein, we employed an integrative approach to a

SUBMITTER: Gupta R 

PROVIDER: S-EPMC8717564 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature