Anti-tuberculosis drug resistance in Slovakia, 2018-2019: The first whole-genome epidemiological study.

ABSTRACT:

Objective

The resistance of Mycobacterium (M.) tuberculosis to antituberculosis drugs poses a major threat to global public health. Whole genome sequencing (WGS) is an increasingly preferred method in the diagnostics and monitoring of the transmission dynamics of resistant forms of tuberculosis (TB). The aim of the study was to, for the first time, use the sequencing-based analysis to study the transmission and resistance patterns of a systematic and recent collection of extensively drug resistant (XDR) and multidrug resistant tuberculosis (MDR-TB) isolates and to expand our knowledge about drug resistant (DR) TB epidemiological dynamics in Slovakia.

Design

A total of 495 patients with pulmonary TB, who were referred to National Reference Laboratory for

SUBMITTER: Dohal M 

PROVIDER: S-EPMC8717600 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature