Proteomic quantitative study of dorsal root ganglia and sciatic nerve in type 2 diabetic mice.

ABSTRACT:

Objective

Peripheral neuropathy is the most common and debilitating complication of type 2 diabetes, leading to sensory loss, dysautonomia, hyperalgesia, and spontaneous noxious sensations. Despite the clinical and economic burden of diabetic neuropathy, no effective treatment is available. More preclinical research must be conducted in order to gain further understanding of the aetiology of the disease and elucidate new therapeutic targets.

Methods

The proteome of lumbar dorsal root ganglia and sciatic nerve of BKS-db/db mice, which contain a mutation of the leptin receptor and are an established type 2 diabetes model, was characterized for the first time by tandem mass tag labelling and mass spectrometry analysis.

Results

Proteomic analysis showed differentially exp

SUBMITTER: Leal-Julia M 

PROVIDER: S-EPMC8717603 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature