Outcomes of intensification of induction chemotherapy for children with high-risk acute myeloid leukemia: A report from the Children's Oncology Group.

ABSTRACT:

Background

High-risk pediatric acute myeloid leukemia confers a poor prognosis, and alternative strategies are needed to improve outcomes. We hypothesized that intensifying induction on the AAML1031 clinical trial would improve outcomes compared to the predecessor trial AAML0531.

Methods

Patients on AAML0531 received cytarabine (1600 mg/m² )/daunorubicin (150 mg/m² )/etoposide (ADE) for induction II and patients on AAML1031 received mitoxantrone (48 mg/m² )/cytarabine (8000 mg/m² ) (MA). Stem cell transplant (SCT) conditioning included busulfan/cyclophosphamide on AAML0531, whereas AAML1031 used busulfan/fludarabine and liberalized donor eligibility. Patients were included in this analysis if they met high-risk criteria common to t

SUBMITTER: Elgarten CW 

PROVIDER: S-EPMC8717610 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature