Dataset Information

Water exchange rate across the blood-brain barrier is associated with CSF amyloid-β 42 in healthy older adults.

ABSTRACT:

Introduction

We tested if water exchange across the blood-brain barrier (BBB), estimated with a noninvasive magnetic resonance imaging (MRI) technique, is associated with cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and neuropsychological function.

Methods

Forty cognitively normal older adults (67-86 years old) were scanned with diffusion-prepared, arterial spin labeling (DP-ASL), which estimates water exchange rate across the BBB (k_w ). Participants also underwent CSF draw and neuropsychological testing. Multiple linear regression models were run with k_w as a predictor of CSF concentrations and neuropsychological scores.

Results

In multiple brain regions, BBB k_w was positively associated with CSF amyloid beta (Aβ)42 concentration levels. BBB k_w was only moderately associated with neuropsychological performance.

Discussion

Our results suggest that low water exchange rate across the BBB is associated with low CSF Aβ42 concentration. These findings suggest that k_w may be a promising noninvasive indicator of BBB Aβ clearance functions, a possibility which should be further tested in future research.

SUBMITTER: Gold BT

PROVIDER: S-EPMC8717840 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Publications

Water exchange rate across the blood-brain barrier is associated with CSF amyloid-β 42 in healthy older adults.

Gold Brian T BT Shao Xingfeng X Sudduth Tiffany L TL Jicha Gregory A GA Wilcock Donna M DM Seago Elayna R ER Wang Danny J J DJJ

Alzheimer's & dementia : the journal of the Alzheimer's Association 20210505 12

<h4>Introduction</h4>We tested if water exchange across the blood-brain barrier (BBB), estimated with a noninvasive magnetic resonance imaging (MRI) technique, is associated with cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and neuropsychological function.<h4>Methods</h4>Forty cognitively normal older adults (67-86 years old) were scanned with diffusion-prepared, arterial spin labeling (DP-ASL), which estimates water exchange rate across the BBB (k<sub>w</sub> ). Participants ...[more]

PMID: 33949773

Similar Datasets

Project description:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and heterozygous HTRA1 mutation-related cerebral small vessel disease (CSVD) are the two types of dominant hereditary CSVD. Blood-brain barrier (BBB) failure has been hypothesized in the pathophysiology of CSVD. However, it is unclear whether there is BBB damage in the two types of hereditary CSVD, especially in heterozygous HTRA1 mutation-related CSVD. In this study, a case-control design was used with two disease groups including CADASIL (n = 24), heterozygous HTRA1 mutation-related CSVD (n = 9) and healthy controls (n = 24). All participants underwent clinical cognitive assessments and brain MRI. Diffusion-prepared pseudo-continuous arterial spin labelling was used to estimate the water exchange rate across the BBB (kw). Correlation and multiple linear regression analyses were used to examine the association between kw and disease burden and neuropsychological performance, respectively. Compared with the healthy controls, kw in the whole brain and multiple brain regions was decreased in both CADASIL and heterozygous HTRA1 mutation-related CSVD patients (Bonferroni-corrected P < 0.007). In the CADASIL group, decreased kw in the whole brain (β = -0.634, P = 0.001), normal-appearing white matter (β = -0.599, P = 0.002) and temporal lobe (β = -0.654, P = 0.001) was significantly associated with higher CSVD score after adjusting for age and sex. Reduced kw in the whole brain was significantly associated with poorer neuropsychological performance after adjusting for age, sex and education in both CADASIL and heterozygous HTRA1 mutation-related CSVD groups (β = 0.458, P = 0.001; β = 0.884, P = 0.008). This study showed that there was decreased water exchange rate across the BBB in both CADASIL and heterozygous HTRA1 mutation-related CSVD patients, suggesting a common pathophysiological mechanism underlying the two types of hereditary CSVD. These results highlight the potential use of kw for monitoring the course of CADASIL and heterozygous HTRA1 mutation-related CSVD, a possibility which should be tested in future research.

Dataset Information

Water exchange rate across the blood-brain barrier is associated with CSF amyloid-β 42 in healthy older adults.

Introduction

Methods

Results

Discussion

Publications

Water exchange rate across the blood-brain barrier is associated with CSF amyloid-β 42 in healthy older adults.

Similar Datasets

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