The Peroxisome-Autophagy Redox Connection: A Double-Edged Sword?

ABSTRACT: Peroxisomes harbor numerous enzymes that can produce or degrade hydrogen peroxide (H₂O₂). Depending on its local concentration and environment, this oxidant can function as a redox signaling molecule or cause stochastic oxidative damage. Currently, it is well-accepted that dysfunctional peroxisomes are selectively removed by the autophagy-lysosome pathway. This process, known as "pexophagy," may serve a protective role in curbing peroxisome-derived oxidative stress. Peroxisomes also have the intrinsic ability to mediate and modulate H₂O₂-driven processes, including (selective) autophagy. However, the molecular mechanisms underlying these phenomena are multifaceted and have only recently begun to receive the attention they deserve. This review pro

SUBMITTER: Li H 

PROVIDER: S-EPMC8717923 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature