SIRT5 Directly Inhibits the PI3K/AKT Pathway in Prostate Cancer Cell Lines.

ABSTRACT:

Background/aim

Prostate cancer (PCa) is the most commonly diagnosed genital cancer in men globally. Among patients who develop advanced PCa, 80% are affected by bone metastasis, with a sharp drop in survival rate. Despite efforts, the details of mechanisms of metastasis of PCa remain unclear. SIRT5, an NAD⁺-dependent deacylase, is hypothesized to be a crucial regulator of various cancers. The role of SIRT5 in cancer has not been extensively studied compared to other SIRTs. In this study, we showed significantly decreased levels of SIRT5 in PC-3M, a highly aggressive PC-3 cell variant.

Materials and methods

We characterized the differentially expressed proteins between parental and SIRT5 KO PC-3 cells using quantitative proteomics analysis.

Results

A signifi

SUBMITTER: Choi SY 

PROVIDER: S-EPMC8717960 | biostudies-literature | 2022 Jan-Feb

REPOSITORIES: biostudies-literature