Transient Ascaris suum larval migration induces intractable chronic pulmonary disease and anemia in mice.

ABSTRACT: Ascariasis is one of the most common infections in the world and associated with significant global morbidity. Ascaris larval migration through the host's lungs is essential for larval development but leads to an exaggerated type-2 host immune response manifesting clinically as acute allergic airway disease. However, whether Ascaris larval migration can subsequently lead to chronic lung diseases remains unknown. Here, we demonstrate that a single episode of Ascaris larval migration through the host lungs induces a chronic pulmonary syndrome of type-2 inflammatory pathology and emphysema accompanied by pulmonary hemorrhage and chronic anemia in a mouse model. Our results reveal that a single episode of Ascaris larval migration through the host lungs leads to permanent lung damage with syste

SUBMITTER: Wu Y 

PROVIDER: S-EPMC8717995 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature