Is muscle and protein loss relevant in long-term fasting in healthy men? A prospective trial on physiological adaptations.

ABSTRACT:

Background

Fasting is attracting an increasing interest as a potential strategy for managing diseases, including metabolic disorders and complementary cancer therapy. Despite concerns of clinicians regarding protein catabolism and muscle loss, evidence-based clinical data in response to long-term fasting in healthy humans are scarce. The objective of this study was to measure clinical constants, metabolic, and muscular response in healthy men during and after a 10 day fast combined with a physical activity programme.

Methods

Sixteen men (44 ± 14 years; 26.2 ± 0.9 kg/m² ) fasted with a supplement of 200-250 kcal/day and up to 3 h daily low-intensity physical activity according to the peer-reviewed Buchinger Wilhelmi protocol. Changes in body weight (BW) and composi

SUBMITTER: Laurens C 

PROVIDER: S-EPMC8718030 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature