Biomarkers related to fatty acid oxidative capacity are predictive for continued weight loss in cachectic cancer patients.

ABSTRACT:

Background

Cachexia is characterized by a negative protein and energy balance leading to loss of adipose tissue and muscle mass. Cancer cachexia negatively impacts treatment tolerability and prognosis. Supportive interventions should be initiated as early as possible. Biomarkers for early prediction of continuing weight loss during the course of disease are currently lacking.

Methods

In this pilot, observational, cross-sectional, case-control study, cachectic cancer patients undergoing systemic first-line cancer treatment were matched 2:1 with healthy controls according to age, gender and body mass index. Alterations in amino acid and energy metabolism, as indicated by acylcarnitine levels, were analysed using mass spectrometry in plasma samples (PS) and dried blood specimen

SUBMITTER: Catanese S 

PROVIDER: S-EPMC8718041 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature