Vitamin D supplementation and risk of falling: outcomes from the randomized, placebo-controlled D-Health Trial.

ABSTRACT:

Background

Falls cause considerable morbidity and mortality in older people. It is unclear how vitamin D supplementation affects falls risk, particularly when taken at high doses. We sought to determine whether monthly high-dose vitamin D supplementation reduces risk and incidence of falls.

Methods

We used data from the randomized, double-blind, placebo-controlled D-Health Trial conducted in Australia. Between February 2014 and May 2015, 21 315 participants aged 60-84 years were randomized (1:1) to monthly doses of either 60 000 IU of colecalciferol or placebo for a maximum of 5 years. People who reported a history of osteomalacia, sarcoidosis, hyperparathyroidism, hypercalcaemia or kidney stones or who were taking >500 IU/day supplementary vitamin D were ineligible. Each ye

SUBMITTER: Waterhouse M 

PROVIDER: S-EPMC8718069 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature