Bile acid metabolism dysregulation associates with cancer cachexia: roles of liver and gut microbiome.

ABSTRACT:

Background

Cancer cachexia is a multifactorial metabolic syndrome in which bile acid (BA) metabolism might be involved. The aim of the present study was to clarify the contribution of liver and gut microbiota to BA metabolism disturbance in cancer cachexia and to check the possibility of targeting BA metabolism using agents such as tauroursodeoxycholic acid (TUDCA) for cancer cachexia therapy.

Methods

The BA profiles in liver, intestine, and serum of mice with cancer cachexia induced by inoculation of colon C26 tumour cells were analysed using metabolomics methods and compared with that of control mice. Proteomic analysis of liver protein expression profile and 16S rRNA gene sequencing analysis of gut microbiota composition in cancer cachexia mice were conducted. Expression

SUBMITTER: Feng L 

PROVIDER: S-EPMC8718071 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature