N-Ammonium Ylide Mediators for Electrochemical C-H Oxidation.

ABSTRACT: The site-specific oxidation of strong C(sp³)-H bonds is of uncontested utility in organic synthesis. From simplifying access to metabolites and late-stage diversification of lead compounds to truncating retrosynthetic plans, there is a growing need for new reagents and methods for achieving such a transformation in both academic and industrial circles. One main drawback of current chemical reagents is the lack of diversity with regard to structure and reactivity that prevents a combinatorial approach for rapid screening to be employed. In that regard, directed evolution still holds the greatest promise for achieving complex C-H oxidations in a variety of complex settings. Herein we present a rationally designed platform that provides a step toward this challenge using N-a

SUBMITTER: Saito M 

PROVIDER: S-EPMC8718116 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature