The Contribution of Astrocyte and Neuronal Panx1 to Seizures Is Model and Brain Region Dependent.

ABSTRACT: Pannexin1 (Panx1) is an ATP release channel expressed in neurons and astrocytes that plays important roles in CNS physiology and pathology. Evidence for the involvement of Panx1 in seizures includes the reduction of epileptiform activity and ictal discharges following Panx1 channel blockade or deletion. However, very little is known about the relative contribution of astrocyte and neuronal Panx1 channels to hyperexcitability. To this end, mice with global and cell type specific deletion of Panx1 were used in one in vivo and two in vitro seizure models. In the low-Mg²⁺ in vitro model, global deletion but not cell-type specific deletion of Panx1 reduced the frequency of epileptiform discharges. This reduced frequency of discharges did not impact the overall po

SUBMITTER: Obot P 

PROVIDER: S-EPMC8718119 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature