Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges.

ABSTRACT: Severe viral pneumonia is a significant cause of morbidity and mortality globally, whether due to outbreaks of endemic viruses, periodic viral epidemics, or the rarer but devastating global viral pandemics. While limited anti-viral therapies exist, there is a paucity of direct therapies to directly attenuate viral pneumonia-induced lung injury, and management therefore remains largely supportive. Mesenchymal stromal/stem cells (MSCs) are receiving considerable attention as a cytotherapeutic for viral pneumonia. Several properties of MSCs position them as a promising therapeutic strategy for viral pneumonia-induced lung injury as demonstrated in pre-clinical studies in relevant models. More recently, early phase clinical studies have demonstrated a reassuring safety profile of these cells.

SUBMITTER: Masterson CH 

PROVIDER: S-EPMC8718182 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature