Activity and Coupling to Hippocampal Oscillations of Median Raphe GABAergic Cells in Awake Mice.

ABSTRACT: Ascending serotonergic/glutamatergic projection from the median raphe region (MRR) to the hippocampal formation regulates both encoding and consolidation of memory and the oscillations associated with them. The firing of various types of MRR neurons exhibits rhythmic modulation coupled to hippocampal oscillatory activity. A possible intermediary between rhythm-generating forebrain regions and entrained ascending modulation may be the GABAergic circuit in the MRR, known to be targeted by a diverse array of top-down inputs. However, the activity of inhibitory MRR neurons in an awake animal is still largely unexplored. In this study, we utilized whole cell patch-clamp, single cell, and multichannel extracellular recordings of GABAergic and non-GABAergic MRR neurons in awake, head-fixed mice.

SUBMITTER: Jelitai M 

PROVIDER: S-EPMC8718440 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature