Characterization of m⁶A RNA Methylation Regulators Predicts Survival and Immunotherapy in Lung Adenocarcinoma.

ABSTRACT: N⁶-methyladenosine (m⁶A) RNA modification is a reversible mechanism that regulates eukaryotic gene expression. Growing evidence has demonstrated an association between m⁶A modification and tumorigenesis and response to immunotherapy. However, the overall influence of m⁶A regulators on the tumor microenvironment and their effect on the response to immunotherapy in lung adenocarcinoma remains to be explored. Here, we comprehensively analyzed the m⁶A modification patterns of 936 lung adenocarcinoma samples based on 24 m⁶A regulators. First, we described the features of genetic variation in these m⁶A regulators. Many m⁶A regulators were aberrantly expressed in tumors and negatively correlated with most tumo

SUBMITTER: Zhu M 

PROVIDER: S-EPMC8718692 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature