Genomic insights in ascending aortic size and distensibility.

ABSTRACT:

Background

Alterations in the anatomic and biomechanical properties of the ascending aorta (AAo) can give rise to various vascular pathologies. The aim of the current study is to gain additional insights in the biology of the AAo size and function.

Methods

We developed an AI based analysis pipeline for the segmentation of the AAo, and the extraction of AAO parameters. We then performed genome-wide association studies of AAo maximum area, AAo minimum area and AAo distensibility in up to 37,910 individuals from the UK Biobank. Variants that were significantly associated with AAo phenotypes were used as instrumental variables in Mendelian randomization analyses to investigate potential causal relationships with coronary artery disease, myocardial infarction, stroke and aneurysm

SUBMITTER: Benjamins JW 

PROVIDER: S-EPMC8718733 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature