Neutrophil Expression of T and B Immunomodulatory Molecules in HIV Infection.

ABSTRACT:

Objective

Evaluate the expression of B and T cell immunomodulatory molecules in polymorphonuclear neutrophils (PMN) in HIV-infected patients.

Methods

HIV load, bacterial translocation and neutrophils' expression of T [programmed death ligand, interleukin-10+, arginase 1+] and B [BAFF, APRIL] molecules were analyzed in different cohorts and time points: a control group of 25 healthy individuals and two groups of HIV-infected patients. Group 1 of patients included 35 untreated patients, studied at baseline and after antiretroviral therapy (ART). Group 2 was composed of 25 patients with undetectable viral load after a median of 101 months of ART prior to inclusion in the study.

Results

Compared with the control group, group 1 patients showed increased bacterial transloca

SUBMITTER: Marquez-Coello M 

PROVIDER: S-EPMC8718872 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature