Early Initiation of Temozolomide Therapy May Improve Response in Aggressive Pituitary Adenomas.

ABSTRACT:

Introduction

Aggressive pituitary adenomas (APAs) are, by definition, resistant to optimal multimodality therapy. The challenge lies in their early recognition and timely management. Temozolomide is increasingly being used in patients with APAs, but evidence supporting a favorable response with early initiation is lacking.

Methods

This was a single-center study of all patients with APAs who received at least 3 cycles of temozolomide (150-200 mg/m²). Their baseline clinico-biochemical and radiological profiles were recorded. Immunohistochemical evaluation for cell-cycle markers O⁶-methylguanine-DNA methyltransferase (MGMT), MutS homolog 2 (MSH2), MutS homolog 6 (MSH6), MutL homolog 1 (MLH1), and postmeiotic segregation increased 2 (PMS2) was performed, a

SUBMITTER: Das L 

PROVIDER: S-EPMC8718901 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature