Genome-wide analysis of the response to ivermectin treatment by a Swedish field population of Haemonchus contortus.

ABSTRACT: Haemonchus contortus is a pathogenic gastrointestinal nematode of small ruminants and, in part due to its capacity to develop resistance to drugs, contributes to significant losses in the animal production sector worldwide. Despite decades of research, comparatively little is known about the specific mechanism(s) driving resistance to drugs such as ivermectin in this species. Here we describe a genome-wide approach to detect evidence of selection by ivermectin treatment in a field population of H. contortus from Sweden, using parasites sampled from the same animals before and seven days after ivermectin exposure followed by whole-genome sequencing. Despite an 89% reduction in parasites recovered after treatment measured by the fecal egg count reduction test, the surviving population was hi

SUBMITTER: Baltrusis P 

PROVIDER: S-EPMC8718930 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature