What is the clinically significant ideal mesenchymal stromal cell count in the management of osteoarthritis of the knee? - Meta-analysis of randomized controlled trials.

ABSTRACT:

Study design

Meta-analysis.

Objectives

We aim to identify the clinically significant ideal Mesenchymal Stem Cell (MSC) count in the management of osteoarthritis of knee from Randomized Controlled Trials (RCTs) available in the literature.

Materials and methods

We conducted independent and duplicate electronic database searches including PubMed, Embase, Web of Science, and Cochrane Library till August 2021 for RCTs conducted in the management of knee osteoarthritis using MSC therapy specifying the quantity of MSCs delivered. We categorized the studies based on the MSC count utilized in them into four groups namely <1 × 10⁷ MSCs (Group I), 1-5x10⁷ MSCs (Group II), 5-10 × 10⁷ MSCs (Group III), and >10 × 10⁷ MSCs (Group IV). Vis

SUBMITTER: Muthu S 

PROVIDER: S-EPMC8719017 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature