Meibomian gland dysfunction and primary Sjogren's syndrome dry eye: a protocol for systematic review and meta-analysis.

ABSTRACT:

Introduction

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disorder that primarily affects the exocrine glands such as the lacrimal and the salivary glands. Dry eye disease (DED) is one of the most prevalent manifestations of pSS and is usually classified into aqueous-deficient dry eye and evaporative dry eye. Sjögren's syndrome dry eye (SSDE) is generally described as aqueous-deficient dry eye. However, as the leading pathophysiological mechanism of evaporative dry eye, meibomian gland dysfunction (MGD) also has influence on SSDE, which has been shown in recent studies. We speculate that SSDE is more than just an aqueous-deficient dry eye. While no related systematic review and meta-analysis has been published, the present study is designed to derive a better understan

SUBMITTER: Zi C 

PROVIDER: S-EPMC8719179 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature