Effects of Gonadotropin-Releasing Hormone Analogs on Ovarian Function Against Chemotherapy-Induced Gonadotoxic Effects in Premenopausal Women With Breast Cancer in China: A Randomized Clinical Trial.

ABSTRACT:

Importance

Studies of the use of gonadotropin-releasing hormone analogs (GnRHa) to protect ovarian function have shown mixed results.

Objective

To determine whether administering GnRHa during chemotherapy in premenopausal women with breast cancer can reduce ovarian impairment.

Design, setting, and participants

This randomized clinical trial, conducted at the Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital and Zhejiang Cancer Hospital in China, was an open-label trial involving premenopausal women aged 18 to 49 years with operable stage I to III breast cancer for which treatment with adjuvant or neoadjuvant cyclophosphamide-containing chemotherapy was planned in 2 parallel groups: treatment with chemotherapy with or without GnRHa. Enrollment o

SUBMITTER: Zong X 

PROVIDER: S-EPMC8719274 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature