A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis.

ABSTRACT: Multiple sclerosis (MS) lesions that do not resolve in the months after they form harbour ongoing demyelination and axon degeneration, and are identifiable in vivo by their paramagnetic rims on MRI scans^1-3. Here, to define mechanisms underlying this disabling, progressive neurodegenerative state^4-6 and foster development of new therapeutic agents, we used MRI-informed single-nucleus RNA sequencing to profile the edge of demyelinated white matter lesions at various stages of inflammation. We uncovered notable glial and immune cell diversity, especially at the chronically inflamed lesion edge. We define 'microglia inflamed in MS' (MIMS) and 'astrocytes inflamed in MS', glial phenotypes that demonstrate neurodegenerative programming. The MIMS transcriptional profile ove

SUBMITTER: Absinta M 

PROVIDER: S-EPMC8719282 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature