Aerobic exercise in older people with subclinical sporadic cerebral small vessel disease: A randomized clinical trial.

ABSTRACT:

Introduction

The benefit and risk of aerobic exercise among older people harboring advanced cerebral small vessel disease (CSVD) upon cognition, mood, and motor functions are unknown.

Methods

This rater-blind randomized trial examined effects of a 24-week aerobic exercise training (60 min/session, twice/week) upon clinical (cognition, mood, motor functions) and hemodynamic (pulse pressure [PP], blood pressure [BP], pulsatility index) measures in older people harboring moderate to severe CSVD, as evidenced by confluent white matter hyperintensity and/or ≥2 lacunes on magnetic resonance imaging. We further investigated interactions between treatment conditions and hemodynamics measures.

Results

Fifty-three and 54 subjects were randomized into the active and control grou

SUBMITTER: Wong A 

PROVIDER: S-EPMC8719349 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature