Biosynthesis of the Fusarium Mycotoxin (-)-Sambutoxin.

ABSTRACT: 4-Hydroxy-2-pyridone alkaloids have attracted attention for synthetic and biosynthetic studies due to their broad biological activities and structural diversity. Here, we elucidated the pathway and chemical logic of (-)-sambutoxin (1) biosynthesis. In particular, we uncovered the enzymatic origin of the tetrahydropyran moiety and showed that the p-hydroxyphenyl group is installed via a late-stage, P450-catalyzed oxidation of the phenylalanine-derived side chain rather than via a direct incorporation of tyrosine.

SUBMITTER: Go EB 

PROVIDER: S-EPMC8719357 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature