White matter changes in empirically derived incident MCI subtypes in the Mayo Clinic Study of Aging.

ABSTRACT:

Introduction

The aim of this study was to examine white matter hyperintensities (WMH) and fractional anisotropy (FA) in empirically derived incident mild cognitive impairment (MCI) subtypes.

Methods

We evaluated 188 participants with incident MCI in the Mayo Clinic Study of Aging (MCSA) identified as having one of four cluster-derived subtypes: subtle cognitive impairment, amnestic, dysnomic, and dysexecutive. We used linear regression models to evaluate whole brain and regional WMH volumes. We examined fractional anisotropy (FA) on a subset of 63 participants with diffusion tensor imaging.

Results

Amnestic and dysexecutive subtypes had higher WMH volumes in differing patterns than cognitively unimpaired; the dysexecutive subtype had higher WMH than subtle cognitive i

SUBMITTER: Machulda MM 

PROVIDER: S-EPMC8719426 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature