Deep learning improves utility of tau PET in the study of Alzheimer's disease.

ABSTRACT:

Introduction

Positron emission tomography (PET) imaging targeting neurofibrillary tau tangles is increasingly used in the study of Alzheimer's disease (AD), but its utility may be limited by conventional quantitative or qualitative evaluation techniques in earlier disease states. Convolutional neural networks (CNNs) are effective in learning spatial patterns for image classification.

Methods

18F-MK6240 (n = 320) and AV-1451 (n = 446) PET images were pooled from multiple studies. We performed iterations with differing permutations of radioligands, heuristics, and architectures. Performance was compared to a standard region of interest (ROI)-based approach on prediction of memory impairment. We visualized attention of the network to illustrate decision making.

Results

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SUBMITTER: Zou J 

PROVIDER: S-EPMC8719427 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature