Protein carbamylation and chronic kidney disease progression in the Chronic Renal Insufficiency Cohort Study.

ABSTRACT:

Background

Protein carbamylation is a post-translational protein modification caused, in part, by exposure to urea's dissociation product cyanate. Carbamylation is linked to cardiovascular outcomes and mortality in dialysis-dependent end-stage kidney disease (ESKD), but its effects in earlier pre-dialysis stages of chronic kidney disease (CKD) are not established.

Methods

We conducted two nested case-control studies within the Chronic Renal Insufficiency Cohort Study. First, we matched 75 cases demonstrating CKD progression [50% estimated glomerular filtration rate (eGFR) reduction or reaching ESKD] to 75 controls (matched on baseline eGFR, 24-h proteinuria, age, sex and race). In the second study, we similarly matched 75 subjects who died during follow-up (cases) to 75 surv

SUBMITTER: Kalim S 

PROVIDER: S-EPMC8719615 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature